Pharmacology:Pharmacodynamics:Anastrozole (ARIMIDEX) is a potent and highly selective non-steroidal aromatase inhibitor. In postmenopausal women, estradiol is produced primarily from the conversion of androstenedione to estrone through the aromatase enzyme complex in peripheral tissues. Estrone is subsequently converted to estradiol. Reducing circulating estradiol levels has been shown to produce a beneficial effect in women with breast cancer. In postmenopausal women, Anastrozole (ARIMIDEX) at a daily dose of 1 mg produced estradiol suppression of greater than 80% using a highly sensitive assay. Anastrozole (ARIMIDEX) does not possess progestogenic, androgenic or estrogenic activity. Daily doses of Anastrozole (ARIMIDEX) up to 10 mg do not have any effect on cortisol or aldosterone secretion, measured before or after standard ACTH challenge testing. Corticoid supplements are therefore not needed. An extensive phase III clinical study programme showed that Anastrozole (ARIMIDEX) is an effective treatment of early breast cancer and advanced breast cancer in postmenopausal women suitable for endocrine therapy.Primary adjuvant treatment of early breast cancer:In a large phase III study conducted in 9366 postmenopausal women with operable breast cancer treated for 5 years, Anastrozole (ARIMIDEX) was shown to be statistically superior to tamoxifen in disease free survival. A greater magnitude of benefit was observed for disease free survival in favour of Anastrozole (ARIMIDEX) versus tamoxifen for the prospectively defined hormone receptor positive population. Anastrozole (ARIMIDEX) was statistically superior to tamoxifen in time to recurrence. The difference was of greater magnitude than in disease free survival for both the Intention-To-Treat (ITT) population and hormone receptor positive population. Anastrozole (ARIMIDEX) was statistically superior to tamoxifen in terms of time to distant recurrence. There was also a numerical trend in favour of Anastrozole (ARIMIDEX) for distant disease free survival. The incidence of contralateral breast cancer was statistically reduced for Anastrozole (ARIMIDEX) compared to tamoxifen. The overall survival benefit of tamoxifen was maintained with Anastrozole (ARIMIDEX). The additional analysis of time to death following recurrence showed a numerical trend in favour of Anastrozole (ARIMIDEX) compared to tamoxifen. Overall, Anastrozole (ARIMIDEX) was well tolerated. The following adverse events were reported regardless of causality. Patients receiving Anastrozole (ARIMIDEX) had a decrease in hot flushes, vaginal bleeding, vaginal discharge, endometrial cancer, venous thromboembolic events and ischemic cerebrovascular events compared with patients receiving tamoxifen. Patients receiving Anastrozole (ARIMIDEX) had an increase in joint disorders (including arthritis, arthrosis and arthralgia) and fractures compared with patients receiving tamoxifen. A fracture rate of 22 per 1000 patient years was observed on Anastrozole (ARIMIDEX) and 15 per 1000 patient years with the tamoxifen group with a median follow up of 68 months. The fracture rate for Anastrozole (ARIMIDEX) falls within the broad range of the fracture rates reported in an age matched postmenopausal population. The combination of Anastrozole (ARIMIDEX) and tamoxifen did not demonstrate any efficacy benefits in comparison with tamoxifen in all patients as well as in the hormone receptor positive population. This treatment arm was discontinued from the study.Adjuvant treatment of early breast cancer for patients being treated with adjuvant tamoxifen:In a phase III trial (ABCSG 8) conducted in 2579 postmenopausal women with hormone receptor positive early breast cancer being treated with adjuvant tamoxifen, patients had a superior disease-free survival when switched to Anastrozole (ARIMIDEX) compared with those continuing on tamoxifen. Time to any recurrence, time to local or distant recurrence and time to distant recurrence confirmed a statistical advantage for Anastrozole (ARIMIDEX), consistent with the results of disease free survival. The incidence of contralateral breast cancer was very low in the two treatment arms, with a numerical advantage for Anastrozole (ARIMIDEX).
clomid online in singapore is amedication used to treat infertility in women who do not ovulate regularly. It can help in the process of getting pregnant after the age of 28. It can also be used to increase fertility in women who do not ovulate.
clomid online in singapore can cause side effects such as hot flashes, mood swings, and abdominal cramping. These symptoms can be more common if the woman is under the age of 35. Clomid can also cause side effects such as mood swings, weight gain, acne, and irregular periods. The side effects of Clomid may be more common if the woman is under the age of 35. If you are experiencing any of the following symptoms, speak with your doctor:
clomid online in singapore can also be used to treat a condition that is not listed on the medication. It can be used to boost your fertility in women who do not ovulate. However, it is not suitable for women who do not have regular menstrual cycles.
Clomid can be used to treat ovulatory dysfunction in women who do not ovulate. It can help in getting pregnant after the age of 35. It can also increase your chances of becoming pregnant after ovulation. Clomid can also help to increase fertility in women who do not ovulate.
The most common side effects of Clomid are nausea, dryness of the vagina, and pain in the upper abdomen. These side effects can be more common if the woman is under the age of 35.
We have with us superior quality CLOMIFENE CITRATE (CLOMID) which are well known among our customers for their high efficiency. Our offered medicines are primarily used for under doctors guidance in various hospitals and clinics.
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Polycystic Ovary Syndrome (PCOS) is not just a condition that affects menstrual cycles or causes ovarian cysts; it can also have a significant impact on the quality of a woman's eggs.
Let's explore how PCOS affects egg quality and what steps can be taken to improve it.
Polycystic Ovary Syndrome is a hormonal imbalance that affects women of reproductive age. One of its most prominent symptoms is irregular ovulation, which in turn affects fertility.
PCOS can disrupt the normal development of eggs in the ovaries. The hormonal imbalances that characterise PCOS can lead to eggs that are less mature or have genetic abnormalities, thus affecting their quality and the chances of successful fertilisation.
Every egg has the potential to be fertilised and develop into an embryo. However, the hormonal imbalances in PCOS can create an unfavourable environment for egg development, leading to lower-quality eggs that may have trouble achieving fertilisation or sustaining a pregnancy.
Drugs like Clomid or Letrozole may be prescribed to stimulate ovulation and improve egg quality in women with PCOS.
A balanced diet and regular exercise can help regulate hormones, thereby potentially improving egg quality.
Supplements like,, and have shown promise in enhancing egg quality in some studies.
In vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI) are advanced fertility treatments that can be considered for women with PCOS who are struggling with poor egg quality.
Always consult a fertility specialist for a personalised treatment plan. Diagnostic tests like antral follicle count or ovarian reserve tests can provide valuable information on your egg quality.
Understanding how PCOS affects egg quality is crucial for anyone struggling with this condition and trying to conceive. Medications, lifestyle changes, and even advanced fertility treatments can offer hope for improving egg quality and achieving a successful pregnancy.
Read More About. More Information. More Information Adithya Mwatsunde Polycystic ovary syndromeIf you have been struggling with PCOS and can't find a specialist, there are several steps you can take to improve the quality of your eggs.
Diet and exercise are essential for improving egg quality and can be helpful for improving egg quality for a woman with PCOS.
Before taking Clomid or Letrozole, before trying toPacini, get a blood test, speak to your doctor, or stop the use of IVF or ICSI.
A balanced diet and regular exercise can improve egg quality and help you to.
When you are taking Clomid or Letrozole, it's important to follow a low-fat and reduced-calorie diet.
Clomiphene citrate (often known by brand names Clomid or Serophene) is a popular fertility medication used to stimulate ovulation and treat infertility in women who do not ovulate regularly. It works by blocking estrogen receptors in the brain, which helps to increase the chances of ovulation. Clomiphene is typically taken orally, usually in the form of a tablet or injection, but can also be taken by mouth or applied topically. In some cases, it can also be taken with food or without it. It is important to follow your doctor’s dosage instructions carefully and not exceed the recommended dosage. When taking Clomid, it’s crucial to be aware of potential side effects, such as hot flashes, mood changes, and visual disturbances. If you experience any unusual or persistent side effects, it is important to consult with your healthcare provider. In conclusion, Clomiphene is a popular fertility drug that can help to stimulate ovulation and improve fertility in women who do not ovulate regularly.
| Type of Clomiphene (Brand Name: Clomid) | || | How to Take Clomid| | How to Take Clomid for Best Results
In conclusion, Clomiphene citrate (often known by brand names Clomid or Serophene) is a popular fertility drug that can help to stimulate ovulation and improve fertility in women who do not ovulate regularly.
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